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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
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Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction

Prathap Kanagala1, Iain B Squire1, Leong L Ng1

  • 1National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University Hospitals of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, United Kingdom.

International Journal of Cardiology. Heart & Vasculature
|August 9, 2017
PubMed

Insights

New biomarkers and advanced imaging show promise for diagnosing heart failure with preserved ejection fraction (HFPEF). These tools complement existing methods like natriuretic peptides and echocardiography for better HFPEF assessment.

Area of Science:

  • Cardiology
  • Biomarkers
  • Medical Imaging

Background:

  • Current heart failure with preserved ejection fraction (HFPEF) diagnosis relies on natriuretic peptides and echocardiography, focusing on diastolic dysfunction.
  • Emerging research identifies novel plasma biomarkers and advanced imaging techniques that could enhance HFPEF diagnostics.

Purpose of the Study:

  • To review the evidence for novel plasma biomarkers, including extracellular matrix (ECM) peptides, galectin-3, ST2, GDF-15, and pentraxin-3, in HFPEF.
  • To explore the utility of advanced imaging techniques in assessing HFPEF, including established parameters and novel evaluations of ECM, myocardial mechanics, and ischemia.

Main Methods:

  • Literature review of existing diagnostic guidelines for HFPEF.
  • Evidence-based review of novel plasma biomarkers (galectin-3, ST2, GDF-15, pentraxin-3).
  • Assessment of capabilities of novel imaging techniques for HFPEF evaluation.

Main Results:

  • Novel plasma biomarkers and advanced imaging offer potential complementary diagnostic tools for HFPEF.
  • These advancements may provide deeper insights into HFPEF pathophysiology beyond current methods.
  • Evaluation of ECM peptides, myocardial mechanics, and ischemia is facilitated by new techniques.

Conclusions:

  • Novel plasma biomarkers and advanced imaging represent a promising frontier in the diagnosis and understanding of HFPEF.
  • Integrating these new tools could refine diagnostic accuracy and therapeutic strategies for HFPEF patients.
  • Further research is warranted to validate and implement these biomarkers and imaging modalities into clinical practice.

Keywords:
BiomarkersExtra-cellular matrixHFPEFImagingPlasma

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