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The association between microhaemorrhages and post - traumatic functional outcome in the chronic phase after mild

S de Haan1, J C de Groot1, B Jacobs2

  • 1Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Neuroradiology
|August 9, 2017
PubMed
Abstract

Insights

Microhaemorrhages in the temporal lobe after mild traumatic brain injury are linked to poor functional outcomes. Susceptibility-weighted imaging (SWI) is the preferred MRI sequence for detecting these brain lesions.

Area of Science:

  • Neuroimaging
  • Neurology
  • Traumatic Brain Injury Research

Background:

  • Microhaemorrhages are common findings on MRI in the chronic phase following mild traumatic brain injury (mTBI).
  • The association between these microhaemorrhages and long-term functional outcomes remains unclear.
  • Identifying the optimal MRI sequence for detecting microhaemorrhages is crucial for understanding their impact.

Purpose of the Study:

  • To investigate the relationship between microhaemorrhages and functional outcomes in patients with chronic mTBI.
  • To determine the most effective MRI sequence for identifying microhaemorrhages associated with functional deficits.

Main Methods:

  • 127 mTBI patients with persistent complaints were analyzed, divided into MRI+ (n=63) and MRI- (n=64) groups.
  • Susceptibility-weighted imaging (SWI) and T2* gradient recalled echo (T2*GRE) were employed to detect microhaemorrhages.
  • Binary logistic regression analyzed the association between microhaemorrhage presence/number/location and functional outcome (Glasgow Outcome Scale Extended).

Main Results:

  • SWI detected significantly more microhaemorrhages (341) than T2*GRE (179).
  • Microhaemorrhages were primarily located in the frontal and temporal lobes.
  • An unfavorable outcome was associated with the number of temporal cortical microhaemorrhages detected by SWI (OR 0.43, p=0.02), explaining 44% of the variance.

Conclusions:

  • The presence and number of temporal cortical microhaemorrhages are associated with unfavorable functional outcomes in the chronic phase after mTBI.
  • SWI is the recommended MRI sequence for detecting microhaemorrhages relevant to functional outcome.
  • Microhaemorrhage count did not correlate with the number of reported post-traumatic complaints.
Keywords:
Functional outcomeMRIMicrohaemorrhagesMild traumatic brain injurySWI and T2*GRE

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