Related Experiment Video
Updated: Feb 25, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication]
S Otte1,2, B Fischer2, F Sayk3
1Sektion Intensivmedizin, Sana Kliniken Lübeck GmbH, Kronsforder Allee 71-73, 23560, Lübeck, Deutschland.
Abstract:
A 25-year-old patient was admitted urgently due to mixed amitriptyline/quetiapine intoxication at a potentially lethal dose. Alongside severe anticholinergic toxidrome, she presented with antiadrenergic and quinidin-like cardiotoxic findings, including ventricular tachycardia. In the present case, arrhythmia and circulatory shock responded neither to alkalization and elevated sodium levels after infusion of sodium bicarbonate, nor to any other established therapies. Following the lipid rescue paradigm, bolus infusion of a 20% lipid emulsion led to rapid stabilization and continued reversal of all intoxication features.
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