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Close association between intestinal microbiota and irritable bowel syndrome
1Medical Technology Institute of Xuzhou Medical University, Xuzhou, 221004, China.
Alterations in gut microbes are linked to irritable bowel syndrome (IBS). This review explores how gut ecosystem changes worsen IBS and introduces probiotics and prebiotics as potential treatments.
Area of Science:
- Gastroenterology
- Microbiology
- Human Physiology
Background:
- The gut microbiome is a complex ecosystem influencing host health and disease.
- Disturbances in the intestinal microflora are associated with various diseases.
- Intestinal microbiota alterations are observed in patients with irritable bowel syndrome (IBS).
Purpose of the Study:
- To review the alterations in intestinal microbiota associated with IBS.
- To discuss how these microbial changes may exacerbate IBS symptoms.
- To introduce novel therapeutic strategies for IBS targeting the gut ecosystem.
Main Methods:
- Literature review focusing on the gut microbiota in IBS.
- Analysis of studies investigating the role of microbial metabolites and host interactions.
- Exploration of emerging treatments, including probiotics and prebiotics.
Main Results:
- Evidence suggests a dysbiotic gut microbial community in IBS patients.
- Microbial alterations can impact gut function and contribute to IBS pathophysiology.
- Probiotics and prebiotics show promise in modulating the gut ecosystem for IBS management.
Conclusions:
- The gut microbiota plays a significant role in IBS development and progression.
- Targeting the gut microbiome offers a promising avenue for IBS treatment.
- Further research into probiotics and prebiotics is warranted for effective IBS therapies.
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