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Gene Editing of Primary Rhesus Macaque B Cells
Published on: February 10, 2023
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Functional polymorphisms in rhesus macaque FCGRT and β2-m
Zhanna Shubin1, Yutaka Tagaya1, Bhawna Poonia2
1Institute of Human Virology, University of Maryland, Baltimore, USA.
Immunogenetics
|August 9, 2017
Summary
Genetic variations in the neonatal Fc receptor (FcRn) in rhesus macaques influence antibody levels. A specific polymorphism in FcRn
Area of Science:
- Immunology
- Genetics
- Primate Models
Background:
- The neonatal Fc receptor (FcRn) is crucial for IgG half-life extension.
- Understanding FcRn genetic variations in rhesus macaques is vital for antibody therapeutic studies.
Purpose of the Study:
- To investigate functional genomic polymorphisms in rhesus macaque FcRn.
- To correlate these polymorphisms with serum IgG and beta-2 microglobulin (β2-m) levels.
Main Methods:
- Genomic DNA sequencing of FcRn genes in 75 rhesus macaques.
- Analysis of serum IgG and β2-m levels.
- Statistical correlation between genetic variants and serum protein levels.
Main Results:
- Identified a VNTR polymorphism in the FcRn promoter and an SNP in the β2-m signal peptide.
- A VNTR minor allele was significantly associated with lower serum IgG levels.
Conclusions:
- FcRn polymorphisms contribute to inter-individual variation in rhesus macaque antibody levels.
- These findings are relevant for designing vaccine and passive immunization studies in this animal model.
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