Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.6K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.6K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.1K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.1K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.2K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.2K
Development of Immunocompetence01:22

Development of Immunocompetence

1.0K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.0K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.1K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

9.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucagon-like peptide receptor agonists (GLP-1RAs) as cardiovascular risk modifiers in obstructive sleep apnea and obesity: a real-world study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Racial and socioeconomic disparities in patients with Waldenström Macroglobulinemia: a SEER database analysis.

Scientific reports·2026
Same author

Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting.

medRxiv : the preprint server for health sciences·2026
Same author

Evolving Concepts of Treatment Targets for Primary Biliary Cholangitis: A Global Perspective.

The American journal of gastroenterology·2026
Same author

Seronegative Autoimmune Hepatitis in Adults Is a Rare Entity Often Obscured by Suboptimal Diagnostic Assessment.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

From science to public health impact: Enacting the recommendations of the EASL-Lancet Commission on liver health in Europe.

Journal of hepatology·2026

Related Experiment Video

Updated: Feb 25, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.5K

Common Variable Immunodeficiency and Liver Involvement.

Junmin Song1,2, Ana Lleo3, Guo Xiang Yang1

  • 1Division of Rheumatology/Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Davis, CA, 95616, USA.

Clinical Reviews in Allergy & Immunology
|August 9, 2017
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) is a B-cell disorder causing recurrent infections and autoimmunity. Understanding CVID

Keywords:
Alkaline phosphataseAutoimmunityB cellCVIDCommon variable immunodeficiencyGranulomaHypogammaglobulinemiaInfectionLiver involvementNodular regenerative hyperplasiaPrimary immunodeficiency

More Related Videos

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

9.2K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.7K

Related Experiment Videos

Last Updated: Feb 25, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.5K
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

9.2K
Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques
11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.7K

Area of Science:

  • Immunology
  • Genetics
  • Hepatology

Background:

  • Common variable immunodeficiency (CVID) is a primary B-cell immunodeficiency characterized by hypogammaglobulinemia.
  • Its etiology is largely unknown, involving B-cell, T-cell, and antigen-presenting cell defects, likely polygenic.
  • CVID patients experience recurrent infections, autoimmunity, lymphoproliferation, and malignancies.

Purpose of the Study:

  • To summarize the current understanding of Common variable immunodeficiency (CVID).
  • To highlight CVID's diverse clinical manifestations, including liver involvement.
  • To discuss diagnostic criteria, treatment, and prognosis.

Main Methods:

  • Review of existing literature on CVID.
  • Analysis of diagnostic criteria (ESID/PAGID).
  • Description of clinical features and management strategies.

Main Results:

  • CVID presents with hypogammaglobulinemia, leading to infections and autoimmune diseases.
  • Autoimmunity can be the sole initial manifestation of CVID.
  • Liver involvement in CVID includes elevated alkaline phosphatase, nodular regenerative hyperplasia, and cirrhosis.

Conclusions:

  • CVID is a complex disorder with varied presentations and largely unknown causes.
  • Early diagnosis and comprehensive management are crucial for improving patient outcomes.
  • Further research into CVID's pathophysiology is needed for targeted therapies, especially for liver complications.