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Current Landscape of Targeted Therapy in Lung Cancer

Manasi K Mayekar1,2,3, Trever G Bivona1,2,3

  • 1Department of Medicine, University of California, San Francisco, San Francisco, USA.

Clinical Pharmacology and Therapeutics
|August 9, 2017
PubMed

Insights

Lung cancer treatment is advancing with targeted therapies. Identifying specific genetic drivers in tumors allows for personalized treatment strategies, improving patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Lung cancer remains a leading cause of cancer-related death globally.
  • Genomic profiling reveals significant heterogeneity and identifies targetable oncogenic drivers in lung tumors.
  • This understanding facilitates the development of molecularly targeted therapies.

Purpose of the Study:

  • To review current clinically approved and emerging molecularly targeted therapies for lung cancer.
  • To discuss challenges associated with these targeted approaches.
  • To explore strategies for overcoming these therapeutic challenges.

Main Methods:

  • Comprehensive genomic profiling of lung cancer tissues.
  • Review of clinical trial data and approved targeted therapies (e.g., EGFR, ALK, ROS1, BRAF V600E inhibitors).
  • Analysis of challenges and proposed solutions in targeted lung cancer treatment.

Main Results:

  • Biomarker-driven patient selection is crucial for effective targeted therapy.
  • Success demonstrated in EGFR, ALK, ROS1, and BRAF V600E inhibitor trials.
  • Numerous targetable alterations have been identified, expanding treatment options.

Conclusions:

  • Molecularly targeted therapies represent a significant advancement in lung cancer treatment.
  • Personalized medicine approaches, guided by genomic profiling, are essential.
  • Addressing challenges in targeted therapy is key to further improving patient survival.

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