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Related Experiment Video

Updated: Feb 25, 2026

Assessing Functional Performance in the Mdx Mouse Model

Assessing Functional Performance in the Mdx Mouse Model

Published on: March 27, 2014

Ventilator-induced diaphragmatic dysfunction in MDX mice.

Feng Liang¹, Tong Li¹, Ilan Azuelos¹

¹Meakins-Christie Laboratories, and Translational Research in Respiratory Diseases Program, McGill University Health Centre and Research Institute, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada.

|August 9, 2017

Summary

This summary is machine-generated.

Mechanical ventilation (MV) rapidly impairs diaphragm function and causes biochemical changes in dystrophic mice, suggesting a risk of ventilator-induced diaphragmatic dysfunction (VIDD) in Duchenne muscular dystrophy (DMD) patients.

Keywords:

Duchenne muscular dystrophy VIDD diaphragm disuse home mechanical ventilation mdx mice neuromuscular disorder

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Assessing Functional Performance in the Mdx Mouse Model

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Published on: March 27, 2014

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Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Area of Science:

Biomedical Engineering
Respiratory Physiology
Muscle Biology

Background:

Duchenne muscular dystrophy (DMD) patients often require mechanical ventilation (MV) for respiratory support.
The impact of MV on the diaphragm in DMD has not been previously investigated.

Purpose of the Study:

To investigate the susceptibility of the dystrophic diaphragm to ventilator-induced diaphragmatic dysfunction (VIDD).

Main Methods:

Dystrophic mdx mice were subjected to 6 hours of MV or served as controls.
Diaphragmatic force production and biochemical markers of stress, metabolism, and proteolysis were assessed.

Main Results:

MV significantly reduced maximal diaphragmatic force production.
MV induced oxidative stress, STAT3 phosphorylation, and upregulated muscle wasting pathways (autophagy, E3 ubiquitin ligases, myostatin).

Conclusions:

Short-term MV causes rapid diaphragm dysfunction and biochemical alterations consistent with VIDD in mdx mice.
Findings suggest potential implications for managing MV in DMD patients.