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Related Concept Videos

Habitat Fragmentation02:31

Habitat Fragmentation

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Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
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Optimal Foraging00:48

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How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Carbon Skeletons01:12

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Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
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Ecological Niches02:02

Ecological Niches

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All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
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Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Related Experiment Video

Updated: Feb 25, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Sarcopenia: Relocating the Forest among the Trees.

Thomas W Buford1

  • 11 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Toxicologic Pathology
|August 9, 2017
PubMed
Summary

Global life expectancy is rising, making age-related muscle loss (sarcopenia) a growing public health issue. More research is needed for effective sarcopenia treatments.

Area of Science:

  • Gerontology
  • Muscle Physiology
  • Public Health

Background:

  • Rising global life expectancy presents new public health challenges.
  • Age-related decline in skeletal muscle mass and function, known as sarcopenia, is a significant concern.
  • Extensive research exists on sarcopenia's pathophysiology, etiology, and clinical impact.

Purpose of the Study:

  • To address the ongoing debates surrounding sarcopenia definition and terminology.
  • To identify and discuss remaining questions regarding sarcopenia interventions.
  • To highlight future challenges in developing effective therapeutic strategies for sarcopenia.

Main Methods:

  • Review of existing literature on sarcopenia.
  • Analysis of current debates on sarcopenia definition and classification.
Keywords:
agingatrophyfrailtyfunctional declineolder adultsskeletal muscle

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  • Identification of knowledge gaps in sarcopenia treatment.

    • Main Results:

    • Despite decades of research, consensus on sarcopenia definition and terminology is still evolving.
    • Significant questions persist regarding the most effective interventions for treating sarcopenia.
    • High-quality clinical trials are crucial for advancing therapeutic strategies.

    Conclusions:

    • Sarcopenia is a critical health issue linked to increased longevity.
    • Further research and standardized definitions are needed.
    • Developing effective treatments for sarcopenia requires rigorous clinical trials.