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Published on: October 6, 2016
Hypertension in people living with HIV
Rosan A van Zoest1, Bert-Jan H van den Born, Peter Reiss
1aDepartment of Global Health, Academic Medical Center, and Amsterdam Institute for Global Health and Development, Amsterdam Health Technology Center bDepartment of Internal Medicine, Division of Vascular Medicine cDepartment of Internal Medicine, Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Academic Medical Center dHIV Monitoring Foundation, Amsterdam, The Netherlands.
Insights
Hypertension is a significant health concern for people living with HIV (PLHIV), with higher prevalence than in the general population. Improving hypertension management is crucial for their cardiovascular health and quality of life.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Hypertension is a growing concern in the HIV-positive population.
- The prevalence of hypertension in people living with HIV (PLHIV) may exceed that in HIV-negative individuals.
Purpose of the Study:
- To review the current understanding of hypertension burden in PLHIV.
- To explore risk factors and clinical management strategies for hypertension in PLHIV.
Main Methods:
- Literature review of existing studies on hypertension in PLHIV.
- Analysis of risk factors, including demographic, genetic, lifestyle, and treatment-related elements.
- Examination of clinical management challenges, focusing on drug interactions.
Main Results:
- Hypertension is highly prevalent in PLHIV, influenced by multiple factors like obesity, ART, and immune activation.
- Key risk factors include demographics, genetics, lifestyle, comorbidities, and antiretroviral therapy (ART).
- Suboptimal awareness, treatment, and control of hypertension in PLHIV necessitate improvement.
Conclusions:
- The multifactorial pathophysiology of hypertension in PLHIV requires further elucidation for targeted interventions.
- Improving hypertension management according to current guidelines is essential for safeguarding cardiovascular health and quality of life in PLHIV.
Purpose Of Review:
This review describes what is known concerning the burden of hypertension among people living with HIV (PLHIV), and also addresses relevant topics with respect to its risk factors and clinical management.
Recent Findings:
Hypertension is highly prevalent in HIV-positive populations, and may be more common than in HIV-negative populations. Risk factors contributing to the development of hypertension in PLHIV include demographic factors, genetic predisposition, lifestyle, comorbidities such as obesity, antiretroviral therapy-related changes in body composition, and potentially also immunodeficiency, immune activation and inflammation, as well as effects from antiretroviral therapy itself. Clinical management of hypertension in PLHIV requires awareness for drug-drug interactions between antiretroviral drugs and antihypertensive drugs. Awareness, treatment, and control of hypertension in PLHIV is currently suboptimal and should be improved.
Summary:
The burden of hypertension among PLHIV is high and its pathophysiology most likely multifactorial. Elucidating the exact pathophysiology of hypertension in PLHIV is vital as this may provide new targets to impact and improve clinical management. In the meantime, efforts should be made to improve hypertension management as per existing clinical guidelines in order to safeguard cardiovascular health and quality of life in PLHIV.
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