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Published on: November 27, 2019
Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure
Luciane Almeida Amado Leon1, Arthur Daniel Rocha Alves, Rita de Cássia Nasser Cubel Garcia
1From the *Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; and †Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, Brasil.
Abstract:
B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined with the detection of anti-B19 Immunoglobulin G (IgG), B19 DNA and B19 mRNA in liver indicate a persistent infection and suggest a diagnosis of parvovirus B19-associated acute liver failure.
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