Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The histopathologic classification of cutaneous lymphomas.

A J Garvin

    Dermatologic Clinics
    |October 1, 1985
    PubMed
    Summary

    A new classification for malignant lymphomas aids in identifying patient groups for therapeutic trials. This system integrates immunologic and morphologic data, refining the Working Formulation for primary cutaneous lymphomas.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents.

    The American journal of pathology·2001
    Same author

    Advances in cytochemical methods for detection of apoptosis.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2001
    Same author

    Recent advances in the diagnosis of pediatric soft-tissue tumors.

    Medical and pediatric oncology·1999
    Same author

    Prognostic significance of Bcl-2 in Wilms' tumor and oncogenic potential of Bcl-X(L) in rare tumor cases.

    International journal of cancer·1999
    Same author

    Establishment and molecular characterization of five cell lines derived from renal and extrarenal malignant rhabdoid tumors.

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·1999
    Same author

    Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.

    Genes & development·1998

    Area of Science:

    • Oncology
    • Immunology
    • Dermatology

    Background:

    • Malignant lymphomas require precise classification for effective treatment strategies.
    • Existing classifications may not fully capture the nuances of primary cutaneous lymphomas.
    • The need for a unified approach integrating immunologic and morphologic data is evident.

    Purpose of the Study:

    • To formulate a classification of malignant lymphomas that identifies distinct clinical patient groups.
    • To integrate the concept of primary cutaneous lymphomas (T-cell or B-cell origin) within the existing Working Formulation.
    • To establish the clinical significance of immunologic data and specific patterns of skin involvement.

    Main Methods:

    • Formulation of a new classification system for malignant lymphomas.
    • Integration of immunologic data alongside traditional morphologic assessment.
    • Analysis of cytomorphologic features and patterns of skin involvement (epidermotropic vs. nonepidermotropic).

    Main Results:

    • The proposed classification encompasses categories within the Working Formulation.
    • Immunologic data is crucial for accurate evaluation of lymphomas.
    • Cytomorphologic subdivision holds less clinical significance for cutaneous T-cell lymphomas compared to cutaneous B-cell lymphomas.

    Conclusions:

    • A unified classification for malignant lymphomas, including primary cutaneous types, is proposed.
    • The classification necessitates both immunologic and morphologic assessments.
    • The pattern of skin involvement in cutaneous T-cell lymphoma is clinically significant and should be incorporated into future classifications.

    Related Experiment Videos