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Related Experiment Video

Updated: Feb 25, 2026

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

Syringe-Injectable Electronics with a Plug-and-Play Input/Output Interface.

Thomas G Schuhmann¹, Jun Yao¹, Guosong Hong¹

¹John A. Paulson School of Engineering and Applied Sciences and ‡Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

|August 9, 2017

Summary

This summary is machine-generated.

New syringe-injectable mesh electronics offer seamless neural integration. This design features user-friendly, plug-and-play connections, simplifying neural prosthetics and brain science research for broader accessibility.

Keywords:

Mesh electronics flat flexible cable (FFC) connector nanoelectronics interface nanowire field-effect transistor neural interface zero insertion force (ZIF) connection

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Published on: November 13, 2019

Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Syringe-injectable mesh electronics offer seamless neural integration but face challenges in input/output (I/O) connectivity.
Existing I/O methods are complex and difficult for life science researchers to implement.

Purpose of the Study:

To develop a novel syringe-injectable mesh electronics design with rapid, scalable, and user-friendly plug-and-play I/O interfacing.
To reduce barriers for nonexpert users in neuroscience and neural prosthetics research.

Main Methods:

Designed mesh electronics with a tapered stem routing interconnects to standard zero insertion force (ZIF) connectors.
Utilized capillary needles for precise, microliter-scale injection and delivery.
Electrically characterized platinum electrodes and silicon nanowire field-effect transistors (NW-FETs).

Main Results:

Demonstrated plug-and-play I/O interfacing with low contact resistance (3 Ω).
Achieved precise in vivo injection into mice with rapid I/O connection (minutes).
Obtained local field potential (LFP) recordings using a compact head-stage compatible with chronic studies.

Conclusions:

The new design significantly lowers the technical barrier for using advanced neural interfaces.
Facilitates broader adoption of mesh electronics in basic and translational neuroscience research.
Enables more sophisticated and multifunctional mesh electronics for future studies.