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Surface Functional Poly(lactic Acid) Electrospun Nanofibers for Biosensor Applications.

Edurne González1, Larissa M Shepherd2, Laura Saunders3

  • 1Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY 14853, USA. eg452@cornell.edu.

Materials (Basel, Switzerland)
|August 10, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed biotin-functionalized poly(lactic acid) nanofibers for biosensor applications. These hydrophilic nanofibers enhance biotin availability for avidin binding, showing promise for point-of-care diagnostics.

Keywords:
avidinbiotinelectrospinningfunctional nanofiberspoly(lactic acid) PLApoly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG)

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biosensor Development

Background:

  • Development of advanced materials for biosensing is crucial for early disease detection.
  • Poly(lactic acid) (PLA) nanofibers offer a versatile platform, but require surface modification for specific biomolecule conjugation.
  • Hydrophilicity and surface functionalization are key properties for effective biosensor performance.

Purpose of the Study:

  • To create biotin surface-functionalized, hydrophilic, biocompatible poly(lactic acid) nanofibers.
  • To investigate the effect of biotin and poly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG) incorporation on nanofiber properties.
  • To evaluate the potential of these nanofibers as biosensors for point-of-care diagnostics.

Main Methods:

  • Incorporation of varying concentrations of biotin (up to 18 wt %) and PLA-b-PEG into PLA nanofibers.
  • Characterization of nanofiber morphology using Field Emission Scanning Electron Microscopy (FESEM).
  • Quantification of surface-available biotin using competitive colorimetric assays.
  • Assessment of fiber water stability through extended water exposure tests.

Main Results:

  • Successful creation of biotin-functionalized, hydrophilic PLA nanofibers.
  • PLA-b-PEG incorporation reduced fiber diameter and significantly increased surface-available biotin for avidin binding.
  • Both biotin and PLA-b-PEG showed migration to the aqueous phase after prolonged water exposure.

Conclusions:

  • The developed functional hydrophilic nanofibers demonstrate significant potential for biosensor applications.
  • The combination of biotin and PLA-b-PEG enhances key properties for biosensing.
  • These nanofibers show promise for future point-of-care diagnostic devices.