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Phosphated Cellulose as an Efficient Biomaterial for Aqueous Drug Ranitidine Removal.

Roosevelt D S Bezerra1, Márcia M F Silva2, Alan I S Morais3

  • 1Federal Institute of Education, Science and Technology of Piauí (IFPI), Campus Teresina-Central, 64000-040 Teresina, Piauí, Brazil. rooseveltdsb@ifpi.edu.br.

Materials (Basel, Switzerland)
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Summary

Chemically modified cellulose, Cel-P10, efficiently sorbs the drug ranitidine. This phosphated biomaterial shows high sorption capacity, making it a promising material for drug removal applications.

Keywords:
cellulosephosphatationranitidinesorptiontrimetaphosphate

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Chemical Modification of Polymers

Background:

  • Cellulose is a widely available biopolymer with potential for chemical modification.
  • Phosphorylation of cellulose can alter its properties for specific applications.
  • Developing efficient methods for drug removal from aqueous solutions is crucial.

Purpose of the Study:

  • To synthesize and characterize phosphated cellulose materials (Cel-P4, Cel-P10).
  • To investigate the efficiency of phosphated cellulose in sorbing the drug ranitidine.
  • To determine the optimal conditions for ranitidine sorption using phosphated cellulose.

Main Methods:

  • Chemical modification of cellulose using sodium trimetaphosphate (STMP) under acidic and basic conditions.
  • Characterization using elemental analysis, XRD, IR, SEM, and NMR.
  • Ranitidine sorption studies under varying pH, time, temperature, and concentration.
  • Kinetic and isotherm modeling (pseudo-second-order, Langmuir).

Main Results:

  • Phosphorylation was more efficient in a basic medium, yielding higher phosphorus content.
  • Phosphated cellulose showed decreased crystallinity, increased roughness, and distinct phosphorus environments.
  • The pseudo-second-order kinetic model and Langmuir isotherm model best described ranitidine sorption.
  • Maximum sorption capacity of 85.7 mg·g⁻¹ was achieved for Cel-P10 at 318 K and pH 6, with saturation at 210 min.

Conclusions:

  • Cel-P10, a phosphated cellulose derivative, is an effective adsorbent for ranitidine.
  • The material exhibits favorable sorption kinetics and isotherm behavior.
  • Optimized conditions (pH 6, 210 min) enhance ranitidine removal efficiency.