Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual-frequency fiber-array photoacoustic computed tomography for high-resolution deep brain imaging.

Light, science & applications·2026
Same author

All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis.

Science advances·2026
Same author

Hierarchically Multifunctional Fiber-optic Theranostic Probe for Cancer Photothermal-photodynamic Synergism.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

A wearable fiber-optoacoustic interface for continuous deep-tissue hemodynamics in MRI environments.

Photoacoustics·2026
Same author

Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy.

Light, science & applications·2026
Same author

Enhanced radio-luminescence and density in amorphous optical glass for X-ray imaging.

Optics express·2026
Same journal

Denoising algorithm of Φ-OTDR systems based on adaptive fractional wavelet transform denoising.

Optics express·2026
Same journal

Millisecond photon-to-photon latency and high-speed volumetric projection system for optogenetics.

Optics express·2026
Same journal

Polarization-encoded coaxial structured light for high-precision 3D surface profilometry.

Optics express·2026
Same journal

Discrete freeform optical design based on collaborative optimization of point cloud and local normals.

Optics express·2026
Same journal

Ultrafast ghost imaging with 25 GHz speckle switching and wavelength-division multiplexing.

Optics express·2026
Same journal

Atomic vapor cells fabricated by femtosecond laser welding of standard-optical-quality glass.

Optics express·2026
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.9K

High-sensitivity DNA biosensor based on microfiber Sagnac interferometer.

Shuai Gao, Li-Peng Sun, Jie Li

    Optics Express
    |August 10, 2017
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel fiber optic biosensor for label-free DNA detection. The high-birefringence microfiber sensor achieves high sensitivity, enabling precise detection of DNA molecules.

    More Related Videos

    Implementation of a Reference Interferometer for Nanodetection
    16:11

    Implementation of a Reference Interferometer for Nanodetection

    Published on: April 26, 2014

    9.8K
    Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
    11:25

    Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

    Published on: April 21, 2016

    11.7K

    Related Experiment Videos

    Last Updated: Feb 25, 2026

    A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
    14:53

    A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

    Published on: September 10, 2014

    17.9K
    Implementation of a Reference Interferometer for Nanodetection
    16:11

    Implementation of a Reference Interferometer for Nanodetection

    Published on: April 26, 2014

    9.8K
    Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
    11:25

    Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

    Published on: April 21, 2016

    11.7K

    Area of Science:

    • Biomedical Engineering
    • Optoelectronics
    • Molecular Diagnostics

    Background:

    • Label-free biosensors offer an alternative to traditional nucleic acid detection methods by eliminating the need for fluorescent labels.
    • Current label-free biosensors, particularly those using optical fiber transducers, face sensitivity limitations due to transducer design.
    • Advancements in optical fiber transducer technology are crucial for enhancing the sensitivity of label-free biosensing platforms.

    Purpose of the Study:

    • To develop a highly sensitive label-free fiber optic biosensor for specific DNA molecule detection.
    • To overcome the sensitivity limitations of existing label-free biosensing technologies.
    • To integrate a novel optical fiber transducer with label-free detection principles.

    Main Methods:

    • Utilized a high-birefringence (Hi-Bi) microfiber Sagnac interferometer.
    • Employed polarimetric interference within the microfiber for label-free detection.
    • Converted target DNA concentration changes into optical wavelength shifts.

    Main Results:

    • Demonstrated a specific detection of DNA molecules.
    • Achieved a log-linear response to target single-stranded DNA (ssDNA) concentrations ranging from 100 picomolar (pM) to 1 micromolar (μM).
    • Established a minimum detectable concentration of 75 pM for ssDNA.

    Conclusions:

    • The developed biosensor offers high sensitivity for label-free DNA detection.
    • The novel Hi-Bi microfiber Sagnac interferometer effectively enhances biosensor performance.
    • This approach presents a promising advancement for sensitive nucleic acid detection in various applications.