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Related Concept Videos

Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

1.4K
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
1.4K
Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

2.0K
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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A Multimodal Wide-Field Fourier-Transform Raman Microscope
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A Multimodal Wide-Field Fourier-Transform Raman Microscope

Published on: December 30, 2025

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Raman imaging through a single multimode fibre.

Ivan Gusachenko, Mingzhou Chen, Kishan Dholakia

    Optics Express
    |August 10, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed the thinnest Raman imaging probe yet, enabling label-free molecular spectroscopy in confined spaces. This breakthrough advances in vivo biomedical analysis and materials science applications.

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    Area of Science:

    • Spectroscopy
    • Biomedical Optics
    • Materials Science

    Background:

    • Vibrational spectroscopy, including Raman spectroscopy, offers label-free molecular analysis.
    • Current fiber Raman probes face limitations in imaging confined geometries, hindering in vivo applications.
    • Advances are needed for compact, flexible probes for deep tissue and organ access.

    Purpose of the Study:

    • To demonstrate Raman spectroscopic imaging using a single multimode fiber.
    • To overcome limitations of current fiber Raman systems in confined spaces.
    • To develop an ultra-thin, flexible Raman imaging probe.

    Main Methods:

    • Utilized complex correction techniques within a single multimode fiber.
    • Eliminated the need for additional optics and filters in the probe design.
    • Achieved Raman spectroscopic imaging with an ultra-thin probe (125 μm diameter).

    Main Results:

    • Demonstrated Raman spectroscopic imaging without compromising compactness or flexibility.
    • Developed the thinnest Raman imaging probe to date.
    • Acquired Raman images of samples, including bacteria, with fields of view over 200 μm.

    Conclusions:

    • This novel approach enables Raman imaging in previously inaccessible confined geometries.
    • The ultra-thin probe design significantly advances the potential for in vivo endoscopic applications.
    • The method retains information content while offering unprecedented probe miniaturization.