Frequency and size of atherosclerotic plaques in vasectomized diabetic monkeys

Male rhesus monkeys were used to elucidate the combined effect of vasectomy and diabetes on frequency and size of atherosclerotic plaques. Four groups were made: in two, bilateral vasectomy was performed, and the other two were subjected to sham vasectomy. Half of the vasectomized and sham-vasectomized monkeys were made diabetic by intravenous injection of alloxan. The animals were observed for a period of one year. Clinical examination revealed bilateral cataract in 40% of the diabetic animals. Marked hyperglycemia along with significant increase of serum triglycerides and free fatty acids was noted in diabetic monkeys. Vasectomy per se did not alter serum lipid levels and overall atherosclerotic plaque score in nondiabetic monkeys. However, the combination of vasectomy with diabetic state led to significant increase of overall atherosclerotic plaque score in coronary and renal arteries.