Related Experiment Video

Updated: Feb 25, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.7K

Cardiac surgery score (CASUS) improves outcome prediction in patients treated with extracorporal life support (ECLS)

Britt Hofmann1, Moriz J Gmelin2, Dietrich Metz1

  • 11 Department of Cardiac Surgery, University Hospital Halle, Germany.

Perfusion
|August 10, 2017
PubMed

Insights

Lactate levels and urine output are early indicators of survival for patients on extracorporeal life support (ECLS). The Cardiac Surgery Score (CASUS) also shows good prognostic ability for ECLS patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Cardiovascular Surgery
  • Intensive Care

Background:

  • Extracorporeal life support (ECLS) is often initiated unexpectedly, limiting early prognostic data.
  • There is a critical need for early indicators to predict outcomes in ECLS patients.
  • Established laboratory parameters and intensive care scores require evaluation for prognostic value in ECLS.

Purpose of the Study:

  • To evaluate established laboratory parameters and intensive care scores as early prognostic indicators for ECLS patients.
  • To identify predictors of in-hospital mortality following ECLS implantation.
  • To compare the prognostic relevance of the Cardiac Surgery Score (CASUS) and Sequential Organ Failure Assessment (SOFA) scores in ECLS.

Main Methods:

  • Retrospective analysis of 90 adult patients undergoing veno-arterial ECLS.
  • Collection of baseline demographic data, laboratory markers, CASUS, and SOFA scores 12 hours post-ECLS implantation.
  • Multivariable regression analysis to identify independent predictors of mortality.

Main Results:

  • 67.8% of patients were successfully weaned from ECLS, and 53.3% were discharged.
  • Lactate levels (OR=1.08) and urine output (OR=0.99) were identified as independent predictors of in-hospital mortality.
  • CASUS (AUROC=0.68) demonstrated higher prognostic relevance than SOFA (AUROC=0.58) for ECLS patients.

Conclusions:

  • Lactate and urine output serve as early, independent predictors of in-hospital mortality in ECLS patients.
  • The CASUS is a valuable tool with good prognostic capabilities for assessing outcomes in this patient population.
  • These findings can aid in early risk stratification and management decisions for ECLS patients.
Abstract

Keywords:
cardiac surgery score (CASUS)extracorporal life support (ECLS)perioperative managementpost-cardiotomy low cardiac output syndrome (LCOS)sequential organ failure assessment (SOFA)

More Related Videos

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

913
Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.3K

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
997
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
520
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
855
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
393