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Published on: September 20, 2019
Effects of lipid-based nutrient supplements v. micronutrient powders on nutritional and developmental outcomes among
Susana L Matias1, Alejandro Vargas-Vásquez2, Ricardo Bado Pérez3
11Department of Nutrition,University of California,Davis,One Shields Avenue,Davis,CA 95616,USA.
Insights
Lipid-based nutrient supplements (LNS) improved hemoglobin and cognitive skills in children aged 6-12 months compared to micronutrient powder (MNP). LNS did not significantly impact linear growth or motor and language development.
Area of Science:
- Pediatric Nutrition
- Public Health Interventions
- Child Development
Background:
- Micronutrient deficiencies are a major global health concern in young children.
- Lipid-based nutrient supplements (LNS) and micronutrient powders (MNP) are common strategies to address these deficiencies.
- Comparative effectiveness of LNS versus MNP on child health outcomes requires further investigation.
Purpose of the Study:
- To compare the effects of LNS versus MNP on hemoglobin (Hb) levels, linear growth, and developmental outcomes in children.
- To evaluate the impact of daily LNS and MNP supplementation over six months on child health indicators.
Main Methods:
- A two-arm parallel-group randomized controlled trial was conducted in rural Peru.
- 422 children aged 6 months were randomized to receive either LNS or MNP for six months.
- Outcomes including Hb, anthropometry, and developmental milestones (motor, language, problem-solving) were assessed at 12 months of age.
Main Results:
- Children receiving LNS showed significantly higher mean Hb concentration and lower odds of anemia compared to the MNP group.
- LNS supplementation was associated with improved problem-solving skills in children.
- No significant differences were observed in anthropometric indicators (stunting, underweight) or gross motor and receptive language development between the groups.
Conclusions:
- LNS supplementation from 6 to 12 months of age effectively increases hemoglobin, reduces anemia, and enhances cognitive development in children.
- LNS did not demonstrate significant benefits over MNP for anthropometric measures or motor and language development.
- These findings support the use of LNS for improving specific health and cognitive outcomes in young children.
Objective:
To determine the effects of lipid-based nutrient supplements (LNS) on children's Hb, linear growth and development, compared with supplementation with micronutrient powder (MNP).
Design:
The study was a two-arm parallel-group randomized controlled trial, where participants received either LNS or MNP for daily consumption during 6 months. Supplements were delivered by staff at government-run health centres. Hb, anthropometric, motor development, language development and problem-solving indicators were measured by trained research assistants when children were 12 months of age.
Setting:
The study was conducted in five rural districts in the Province of Ambo in the Department of Huánuco, Peru.
Subjects:
We enrolled 6-month-old children (n 422) at nineteen health centres.
Results:
Children who received LNS had a higher mean Hb concentration and lower odds of anaemia than those who received MNP. No significant differences in height-for-age, weight-for-height or weight-for-age Z-score, or stunting and underweight prevalence, were observed. Provision of LNS was associated with a higher pre-verbal language (gestures) score, but such effect lost significance after adjustment for covariates. Children in the LNS group had higher problem-solving task scores and increased odds of achieving this cognitive task than children in the MNP group. No significant differences were observed on receptive language or gross motor development.
Conclusions:
LNS between 6 and 12 months of age increased Hb concentration, reduced anaemia and improved cognitive development in children, but showed no effects on anthropometric indicators, motor or language development.
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