Related Experiment Video For Alternative splicing
Updated: Feb 25, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity
Daniel P Neumann1, Gregory J Goodall2, Philip A Gregory3
1Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia.
Abstract:
Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes.
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