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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Imaging Studies IV: Magnetic Resonance Imaging01:27

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Tau-imaging in neurodegeneration.

Gérard N Bischof1, Heike Endepols1, Thilo van Eimeren2

  • 1Department of Nuclear Medicine, University of Cologne, Germany.

Methods (San Diego, Calif.)
|August 10, 2017
PubMed
Summary

Novel molecular imaging tracers for tau-protein aggregates show promise for diagnosing neurodegenerative diseases like Alzheimer's disease (AD). Further research is needed to overcome challenges in standardization and interpretation for clinical use.

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Area of Science:

  • Neuroscience
  • Molecular Imaging
  • Biochemistry

Background:

  • Pathological protein aggregations in the brain are key to neurodegenerative disorders.
  • Alzheimer's disease (AD) is characterized by amyloid-plaques and tau tangles.
  • New tracers for in vivo tau-aggregate imaging complement amyloid imaging.

Purpose of the Study:

  • To review the complexity and challenges of novel tau-positron emission tomography (Tau-PET) tracers.
  • To discuss the potential clinical applications of Tau-PET imaging.

Main Methods:

  • Review of available data on novel tau-PET tracers.
  • Analysis of challenges in tracer validation, standardization, and interpretation.

Main Results:

  • Tau-PET imaging is complex due to diverse tau pathology presentations.
  • Hurdles include tracer comparability, off-target binding, and quantitative signal interpretation.
  • Systematic clinical application requires clarification of these issues.

Conclusions:

  • Tau-PET tracers offer potential for early neurodegeneration detection and differential diagnosis.
  • Patient selection and monitoring in therapy trials are potential applications.
  • Further validation is crucial for widespread clinical adoption of Tau-PET imaging.