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Related Experiment Video

Updated: Feb 25, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Orbital multiple myeloma: a diagnostic challenge.

Evelyn Tai1, See Khim Sim2,3, Juhara Haron3

  • 1Department of Ophthalmology, University Sains Malaysia - Health Campus, Kubang Kerian, Malaysia.

BMJ Case Reports
|August 10, 2017
PubMed
Summary
This summary is machine-generated.

Orbital involvement in multiple myeloma is rare. This case highlights the diagnostic imaging challenges of orbital multiple myeloma, presenting as a sphenoid wing mass in an elderly woman.

Keywords:
Malignant And Benign HaematologyMedical EducationOphthalmologyRadiology

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Area of Science:

  • Ophthalmology
  • Oncology
  • Radiology

Background:

  • Multiple myeloma rarely involves the orbit.
  • Early diagnosis is crucial for managing orbital tumors.

Observation:

  • An 85-year-old woman presented with proptosis, decreased vision, and double vision.
  • CT imaging revealed a soft tissue mass involving the sphenoid wing, orbit, and ocular muscles.

Findings:

  • Histopathology confirmed atypical plasma cells with kappa light chain monoclonality, indicative of multiple myeloma.
  • The imaging findings presented a diagnostic challenge for orbital multiple myeloma.

Implications:

  • This case underscores the importance of considering multiple myeloma in orbital masses.
  • Advanced imaging and histopathology are key to diagnosing rare orbital presentations of multiple myeloma.