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MALDI-TOF Mass Spectrometry

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Updated: Feb 25, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

A clinician's guide to microbiome analysis.

Marcus J Claesson^1,2, Adam G Clooney^1,2,3, Paul W O'Toole^1,2

¹School of Microbiology, University College Cork, Western Road, T12 Y337 Cork, Ireland.

Nature Reviews. Gastroenterology & Hepatology

|August 10, 2017

Summary

This summary is machine-generated.

Microbiome analysis offers new ways to understand patient health using gut microbiota. This review guides researchers on technology choices for microbiome studies and their clinical potential.

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Last Updated: Feb 25, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Published on: October 15, 2019

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

Area of Science:

Microbiome research
Gastroenterology
Clinical applications

Background:

Microbiome analysis determines microbial community composition and function.
Gut microbiota alterations correlate with various diseases.
Microbiota are targets for biomarkers and therapeutics.

Purpose of the Study:

To summarize key decisions for new microbiome researchers.
To provide recommendations on sequencing technology.
To offer perspectives on future clinical applications.

Main Methods:

Review of current microbiome research technologies.
Analysis of sequencing platform options.
Expert experience in microbiome project design.

Main Results:

Identification of major decision points in microbiome research.
Recommendations for selecting sequencing platforms.
Insights into the evolving landscape of microbiome analysis.

Conclusions:

Microbiome research presents significant opportunities for gastroenterology.
Technology choices impact the success of microbiome studies.
Future applications promise advancements in disease detection and management.