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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Personomics and Precision Medicine.

Roy C Ziegelstein1

  • 1BALTIMORE, MARYLAND.

Transactions of the American Clinical and Climatological Association
|August 10, 2017
PubMed
Summary
This summary is machine-generated.

Understanding the whole patient, or "personomics," is crucial for effective medical care. This involves considering psychological, social, and cultural factors alongside genomics for personalized treatment.

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Area of Science:

  • Medical Humanities
  • Personalized Medicine
  • Sociology of Health

Background:

  • Historically, patient individuality was central to medicine.
  • Modern healthcare faces challenges like shorter visits, technology reliance, and diverse patient populations, hindering communication.
  • An overemphasis on quantifiable data may overshadow holistic patient understanding.

Purpose of the Study:

  • To highlight the critical importance of understanding the individual patient beyond measurable data.
  • To introduce and define 'personomics' as a vital component of patient care.
  • To emphasize the need to integrate psychological, social, cultural, behavioral, and economic factors into medical practice.

Main Methods:

  • Conceptual analysis of the evolution of patient care.
  • Discussion of challenges in contemporary physician-patient communication.
  • Integration of omics sciences with holistic patient assessment.

Main Results:

  • Personomics, encompassing individual circumstances, is as critical as genomics for patient care.
  • Psychosocial, cultural, behavioral, and economic factors significantly influence disease presentation and treatment response.
  • A comprehensive understanding of the patient is essential for accurate diagnosis and effective therapy.

Conclusions:

  • Personomics provides a framework for understanding how individual factors shape disease.
  • Integrating personomics with biomedical data leads to more precise diagnostics and therapeutics.
  • Holistic patient assessment is fundamental for optimizing health outcomes and personalized treatment strategies.