ANTIBIOTIC RESISTANCE PATTERN OF ISOLATES FROM WOUND AND SOFT TISSUE INFECTIONS

Area of Science:

• Clinical Microbiology
• Infectious Diseases
• Antimicrobial Resistance

Background:

• Wound and soft tissue infections are significant clinical challenges.
• Understanding causative pathogens and their antibiotic susceptibility is crucial for effective treatment.
• Distinguishing between community-acquired and nosocomial infections aids in epidemiological analysis.

Purpose of the Study:

• To identify bacterial species causing wound and soft tissue infections.
• To determine the antibiotic resistance patterns of these bacterial isolates.
• To evaluate the efficacy of different antibiotics for empirical therapy.

Main Methods:

• Bacterial isolates (n=280) from wound and soft tissue infections were collected.
• Isolates were categorized into community-acquired (n=122) and nosocomial (n=158) infections.
• Species identification and antibiotic susceptibility testing were performed using standard microbiological techniques.

Main Results:

• Staphylococcus aureus was the most common pathogen in both community-acquired (67.8%) and nosocomial (60.1%) infections.
• High resistance rates were observed for penicillin (87-92%) and ampicillin (85% in Proteus).
• Methicillin-resistant Staphylococcus aureus (MRSA) exhibited higher resistance to other antibiotics. Amikacin (80.7%) and ofloxacin (80.4%) showed the highest susceptibility rates.

Conclusions:

• Significant antibiotic resistance exists among bacteria causing wound and soft tissue infections.
• Staphylococcus aureus is a predominant pathogen, with notable resistance patterns.
• Amikacin and ofloxacin are recommended as effective empirical therapy options.