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Dengue Virus Glycosylation: What Do We Know?
Sally S L Yap1, Terry Nguyen-Khuong2, Pauline M Rudd2
1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology program, Life Sciences Institute, National University of SingaporeSingapore, Singapore.
Frontiers in Microbiology
|August 10, 2017
Summary
Glycosylation of Dengue virus (DENV) envelope (E) and non-structural protein 1 (NS1) is crucial for viral infection. This review summarizes current knowledge on DENV protein glycosylation, its role in pathogenesis, and potential as a vaccine target.
Area of Science:
- Virology
- Glycobiology
- Immunology
Background:
- Pathogen glycoproteins are vital for infectious cycles, including host immune evasion.
- Dengue virus (DENV) envelope (E) and non-structural protein 1 (NS1) are key vaccine candidates.
- The role of glycosylation in DENV E and NS1 proteins remains understudied.
Purpose of the Study:
- To comprehensively review current knowledge on protein glycosylation in Dengue virus.
- To elucidate the biological importance of glycosylated DENV proteins.
- To explore the role of glycosylation in DENV pathogenesis and vaccine development.
Main Methods:
- Literature review of existing studies on Dengue virus protein glycosylation.
- Analysis of the impact of glycosylation on DENV E and NS1 protein functions.
- Synthesis of information regarding glycosylation's role in DENV biogenesis, host interaction, and disease.
Main Results:
- DENV E protein glycosylation influences antibody binding and neutralization.
- NS1 glycosylation affects its secretion, interaction with host factors, and immune response.
- Glycosylation impacts DENV virion assembly, stability, and infectivity.
Conclusions:
- Protein glycosylation is a critical but underappreciated aspect of DENV biology.
- Understanding DENV glycosylation is essential for developing effective vaccines and therapeutics.
- Further research into DENV glycosylation can reveal novel targets for controlling dengue disease.
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