Related Experiment Video
Updated: Feb 25, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
The underactive bladder: diagnosis and surgical treatment options
Johan Gani1,2, Derek Hennessey1
1Department of Urology, Austin Hospital, Heidelberg, Victoria, Australia.
Underactive bladder (UAB) or detrusor underactivity (DU) is common and challenging to manage. This review covers UAB/DU diagnosis and surgical treatments like TURP and sacral neuromodulation (SNM).
Area of Science:
- Urology
- Geriatrics
Background:
- Underactive bladder (UAB), also known as detrusor underactivity (DU), is a prevalent condition, particularly in older adults.
- DU affects up to 45% of individuals over 70 and presents diagnostic and management challenges due to symptom overlap with overactive bladder (OAB) and bladder outlet obstruction (BOO).
Purpose of the Study:
- To review the diagnostic approaches for UAB/DU.
- To provide an overview of various surgical treatment options for UAB/DU.
Main Methods:
- A comprehensive literature review was conducted using major medical search engines.
- Keywords included UAB, DU, TURP, reduction cystoplasty, bladder diverticulectomy, and sacral neuromodulation (SNM).
- Relevant literature was assessed for definitions, general overview, and management strategies.
Main Results:
- Urodynamic findings for DU include low voiding pressure, slow flow, and incomplete emptying.
- Transurethral resection of the prostate (TURP) offers feasible short-to-medium term benefits for DU, though symptoms may return.
- Bladder diverticulectomy and sacral neuromodulation (SNM) can improve DU, with patient selection being crucial for SNM success.
Conclusions:
- Effective diagnosis and management of UAB/DU require careful consideration of urodynamic findings and patient characteristics.
- Surgical interventions like TURP, bladder diverticulectomy, and SNM present viable options, each with specific indications and outcomes.
- Optimizing patient selection is key to achieving successful outcomes with surgical treatments for UAB/DU.
Related Concept Videos
Urinary Tract Calculi VI: Surgical Management
Urinary Tract Calculi III: Medical Management
Imaging Studies VI: Voiding Cystourethrography and Cystography
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Imaging Studies II: Ultrasonography

