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Ralstonia infection in cystic fibrosis
H D Green1, R Bright-Thomas1, D T Kenna2
1University Hospital of South Manchester NHS Foundation Trust, Manchester Adult Cystic Fibrosis Centre,Manchester,UK.
Epidemiology and Infection
|August 10, 2017
Summary
Prevalence of Ralstonia species in cystic fibrosis patients is increasing. Most infected patients develop chronic infections, and cross-infection is possible, impacting lung function.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pulmonology
Background:
- Ralstonia species are emerging pathogens in healthcare settings.
- Cystic fibrosis patients are susceptible to chronic respiratory infections.
- Understanding Ralstonia spp. epidemiology in CF is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of Ralstonia species in cystic fibrosis (CF) patients.
- To investigate potential cross-infection events among CF patients.
- To describe clinical outcomes associated with Ralstonia species infection.
Main Methods:
- Annual prevalence calculation of Ralstonia species from 2008 to 2016.
- Pulsed-field gel electrophoresis (PFGE) for strain typing of isolated Ralstonia species.
- Prospective, longitudinal observational study with 12-month follow-up for adult CF patients.
Main Results:
- Ralstonia species prevalence increased from 0.6% in 2008 to 2.4% in 2016.
- 86% of patients with Ralstonia species isolation developed chronic infections.
- Shared Ralstonia mannitolilytica strains were identified in unrelated patients, suggesting cross-transmission.
- Infected patients experienced moderate to severe lung function impairment.
Conclusions:
- Ralstonia species infection in CF patients is increasing, though prevalence remains low.
- High risk of developing chronic infection post-acquisition and potential for cross-infection.
- Further large-scale studies are needed to confirm the impact on pulmonary exacerbations and lung function decline.
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