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HCV co-infection is associated with metabolic abnormalities among HAART naive HIV-infected persons

M A Kuti1, J O Akinyemi2, B O Ogunbosi3

  • 1Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.

Nigerian Journal of Clinical Practice
|August 10, 2017
PubMed

Insights

Hepatitis C Virus (HCV) co-infection in HIV-infected individuals may lower cholesterol levels but fasting plasma glucose may not indicate insulin resistance. This study examined metabolic changes in co-infected patients.

Area of Science:

  • Infectious Diseases
  • Metabolic Disorders
  • Hepatology

Background:

  • Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) co-infection is prevalent in certain populations.
  • Metabolic abnormalities are common in individuals with chronic viral infections.
  • Understanding these metabolic changes is crucial for managing co-infected patients.

Purpose of the Study:

  • To investigate metabolic abnormalities in treatment-naïve, HIV-infected individuals with Hepatitis C Virus (HCV) co-infection.
  • To assess fasting plasma glucose (FPG) and lipid profiles in this co-infected population.
  • To determine the relationship between HIV-HCV co-infection and metabolic parameters.

Main Methods:

  • Retrospective review of clinical records of newly recruited HIV-infected patients.
  • Analysis of baseline fasting plasma glucose and fasting lipid profiles.
  • Comparison of metabolic parameters between HIV-HCV co-infected and HIV-only infected individuals.

Main Results:

  • HCV co-infection was found in 6% of the 1,260 HIV-infected individuals studied.
  • HIV-HCV co-infection was associated with lower median total cholesterol, LDL-cholesterol, and HDL-cholesterol.
  • Median FPG was significantly higher in co-infected individuals, but no relationship was found with fasting glucose levels via regression analysis.

Conclusions:

  • HIV-HCV co-infection appears linked to a decrease in plasma cholesterol levels.
  • Fasting plasma glucose alone may be insufficient to identify insulin resistance in HIV-HCV co-infected individuals.
  • Further research is needed to fully understand the metabolic implications of HIV-HCV co-infection.
Abstract

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