Related Experiment Video
Updated: Feb 25, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
5.6K
Association Between ABCB1 Gene Polymorphism and Renal Function in Patients with Hypertension: A Case-Control Study
Xiaofang Chen1, Tao Zhou2, Deguang Yang2
1Department of Nursing, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
Summary
The ABCB1 gene, specifically the rs1045642-T allele, may increase the risk of kidney damage in patients with hypertension. This genetic factor is linked to renal function injury in hypertensive individuals.
Area of Science:
- Genetics
- Nephrology
- Cardiology
Background:
- Hypertension is a significant risk factor for target organ damage.
- Genetic factors are implicated in hypertension-related organ damage.
- The role of the ABCB1 gene in hypertension-induced renal injury requires further investigation.
Purpose of the Study:
- To investigate the association between ABCB1 gene polymorphisms and renal function injury in hypertensive patients.
- To identify potential genetic markers for predicting renal complications in hypertension.
Main Methods:
- A case-control study design was employed.
- Patients with hypertension were recruited, and their clinical data and ABCB1 gene polymorphisms (rs1045642, rs10808072, rs1922242) were analyzed using restriction fragment length polymorphism.
- Statistical analyses, including multivariable logistic regression, were used to determine associations.
Main Results:
- Hypertensive patients exhibited higher BMI, systolic blood pressure, total cholesterol, blood urea nitrogen, creatinine, uric acid, estimated glomerular filtration rate, and platelet levels compared to controls.
- A statistically significant difference in genotype frequency distribution was observed for the ABCB1 rs1045642 polymorphism (p<0.001).
- The TT genotype of rs1045642 was associated with a higher risk of renal function injury in hypertensive patients (OR=3.47, 95% CI: 1.19-10.07).
Conclusions:
- The rs1045642-T allele of the ABCB1 gene is potentially associated with an increased risk of renal function injury in hypertensive patients.
- ABCB1 gene polymorphisms may serve as a genetic marker for renal complications in hypertension.
- Further research is warranted to elucidate the precise mechanisms linking ABCB1 and hypertensive kidney disease.
Related Concept Videos
01:16Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
68
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
68
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
26
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
26
01:18Hypertension and Regulation of Blood Pressure
4.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
45
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
45
01:17Antihypertensive Drugs: Action of β1 Blockers
2.2K
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
2.2K
01:27Principles of Pharmacogenetics: Types of Genetic Variants
31
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
31