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Identification of Characters and Localization of Images Using Direct Multiple-Electrode Stimulation With a

Mohit N Shivdasani1,2, Nicholas C Sinclair1,2, Lisa N Gillespie1

  • 1Bionics Institute, East Melbourne, Victoria, Australia.

Investigative Ophthalmology & Visual Science
|August 10, 2017
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This study shows that suprachoroidal retinal prostheses can help blind patients identify characters and locate images. Performance varied, emphasizing the need for spatial cues and eye-movement compensation for better vision restoration.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Neuroscience

Background:

  • Retinal prostheses aim to restore vision in blind individuals by electrically stimulating the retina to create phosphenes.
  • Suprachoroidal electrode arrays represent a promising approach for retinal implantation due to their minimally invasive nature.

Purpose of the Study:

  • To investigate the feasibility of character identification and image localization using direct multi-electrode stimulation with a suprachoroidal retinal prosthesis.
  • To assess the impact of electrode stimulation patterns on visual perception in patients with retinitis pigmentosa.

Main Methods:

  • Three psychophysical tasks were administered to two retinitis pigmentosa patients implanted with a suprachoroidal electrode array.
  • Stimulation patterns were designed to elicit specific character perceptions and test percept localization with static and dynamic images.
  • Eye-tracking technology was employed to correlate accuracy with eye movement patterns.

Main Results:

  • Character identification accuracy varied significantly (2.7%–93.3%) across patients and characters.
  • Image localization accuracy was dependent on contrast, decreasing significantly at lower levels for one patient.
  • One patient demonstrated trajectory recognition of dynamic images up to 64 deg/s, while the other performed near chance.
  • Patient accuracy correlated with eye movements and stimulus direction.

Conclusions:

  • The suprachoroidal device demonstrated potential for providing meaningful visual information, enabling character identification and percept localization.
  • Performance variability underscores the critical role of spatial cues from phosphenes, particularly challenging at low contrast.
  • Integrating spatial information from multiple electrodes and eye-movement compensation strategies is crucial for enhancing real-world prosthesis functionality in camera-based systems.