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Interaction effect between 5-HTTLPR and HTR1A rs6295 polymorphisms on the frontoparietal network.

Haixia Long¹, Bing Liu², Chao Wang³

¹College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.

|August 10, 2017

Summary

This study reveals how serotonin transporter (5-HTTLPR) and serotonin 1A receptor (rs6295) gene variants interact to affect brain connectivity, impacting working memory (WM) performance in young adults.

Keywords:

5-HTTLPR HTR1A rs6295 frontoparietal network gene–gene interaction resting-state network

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Area of Science:

Neuroscience
Genetics
Cognitive Psychology

Background:

The serotonin system is closely linked to working memory (WM), but its precise neural mechanisms remain unclear.
The frontoparietal network is crucial for WM and interacts with the serotonin system.

Purpose of the Study:

To investigate the interaction effect of serotonin transporter-linked polymorphic region (5-HTTLPR) and serotonin 1A receptor gene (rs6295) polymorphism on the frontoparietal network.
To explore the neural basis of gene-gene interactions influencing cognitive functions, specifically WM.

Main Methods:

Utilized independent component analysis (ICA) to examine the frontoparietal network in a large, young Chinese sample.
Analyzed the interaction between 5-HTTLPR and rs6295 genotypes on brain connectivity.

Main Results:

A significant interaction effect between 5-HTTLPR and rs6295 was observed on the connectivity of the right frontoparietal network.
This interaction specifically involved the middle frontal gyrus and inferior parietal lobule.
Connectivity in the right inferior parietal lobule positively correlated with WM performance.

Conclusions:

Gene-gene interactions, specifically between 5-HTTLPR and rs6295, modulate frontoparietal network connectivity.
These findings offer novel insights into the neural mechanisms underlying individual differences in working memory.