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Updated: Feb 25, 2026

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
Published on: August 2, 2024
Extended Interneuronal Network of the Dentate Gyrus
Gergely G Szabo1, Xi Du2, Mikko Oijala1
1Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Abstract:
Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.
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