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Resistance of Gerbil Auditory Function to Reversible Decrease in Cochlear Blood Flow.

Fahd El Afia1, Fabrice Giraudet, Laurent Gilain

  • 1Neurosensory Biophysics, INSERM UMR 1107, University of Auvergne, Clermont-Ferrand, France.

Audiology & Neuro-Otology
|August 10, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed a reversible model for reducing cochlear blood flow (CBF) in gerbils. The study found that cochlear function remains robust even with significant CBF reduction, suggesting resilience to hypoperfusion.

Keywords:
Cerebellopontine angleCochlear blood flowCochlear microphonic potential

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Area of Science:

  • Oto-rhino-laryngology
  • Physiology
  • Medical Engineering

Background:

  • Cochlear blood flow (CBF) is critical for maintaining auditory function.
  • Understanding the impact of reduced CBF on cochlear function is essential for diagnosing and treating hearing loss.
  • Existing models for studying CBF alterations are often invasive or irreversible.

Purpose of the Study:

  • To design a novel, reversible model in gerbils to decrease cochlear blood flow (CBF).
  • To analyze the influence of transient CBF reduction on cochlear function, specifically the cochlear microphonic potential (CM) and neural responses.
  • To establish a tool for investigating cochlear sensitivity to hypoperfusion.

Main Methods:

  • Mongolian gerbils were injected with ferromagnetic microbeads.
  • A magnet was placed near the porus acusticus to control and reduce CBF.
  • Cochlear microphonic potential (CM) was monitored using a round-window electrode.
  • Auditory brainstem responses (ABRs) were used to assess neural function and threshold elevation.

Main Results:

  • A stable, reversible reduction in CBF was achieved in 13 out of 20 gerbils for an average of 11.5 minutes.
  • CM was significantly affected only when CBF decreased to below 60% of baseline.
  • Despite CBF reduction, CM remained above 40% of its initial level in approximately two-thirds of affected cases, with rapid and complete recovery upon CBF restoration.
  • Neural response thresholds, measured by compound action potentials, showed a 35- to 45-dB elevation correlating with reduced CM.

Conclusions:

  • The developed model allows for controlled, reversible manipulation of CBF in gerbils.
  • Cochlear function demonstrates significant robustness and resilience to temporary decreases in CBF.
  • This model serves as a valuable tool for studying the effects of hypoperfusion and potential stress sensitivity in the cochlea.