Related Experiment Video
Updated: Feb 25, 2026
10:24
Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
Published on: May 9, 2016
17.8K
Mineralized Collagen: Rationale, Current Status, and Clinical Applications
Zhi-Ye Qiu1,2, Yun Cui3, Chun-Sheng Tao4,5
1School of Materials Science and Engineering, Tsinghua University, Haidian District, Beijing 100084, China. ye841215@gmail.com.
Materials (Basel, Switzerland)
|August 11, 2017
Summary
This review covers mineralized collagen, focusing on its in vitro preparation and clinical uses. Biomimetic bone substitutes derived from mineralized collagen show promise in medical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomineralization
Background:
- Mineralized collagen is a key component of natural bone.
- Understanding its formation is crucial for developing bone substitutes.
- Decades of research have explored natural mineralized collagen.
Purpose of the Study:
- To review the rationale behind in vitro mineralization.
- To discuss preparation methods for biomimetic mineralized collagen.
- To explore the clinical applications and outcomes of mineralized collagen.
Main Methods:
- Literature review of studies on mineralized collagen.
- Analysis of biomimetic material preparation techniques.
- Examination of clinical case reports and regulatory approvals.
Main Results:
- Biomimetic materials mimicking natural mineralized collagen have been developed.
- Several bone substitute materials based on mineralized collagen are commercialized.
- Clinical outcomes demonstrate the significance of these materials.
Conclusions:
- Mineralized collagen research has led to successful bone substitute development.
- Commercialized products show regulatory approval and clinical utility.
- Ongoing clinical studies will further refine and evaluate mineralized collagen applications.
Related Concept Videos
01:11Fibril-associated Collagen
3.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
01:18The Bone Matrix
6.0K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.0K
01:56Structural Protein Function
30.2K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
30.2K
01:22Connective Tissue Cell Types
4.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.3K
01:13Collagens are the Major Structural Proteins of ECM
6.0K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
6.0K
01:05Type IV Collagen of Basal Lamina
3.2K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
3.2K