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Related Experiment Videos

Mastocytosis: one year's experience.

S L Burklow, S R Marney

    Southern Medical Journal
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Systemic mastocytosis is increasingly diagnosed. This study found ten cases among 490 patients, with symptoms like flushing and abdominal issues managed by medication.

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    Area of Science:

    • Dermatology
    • Allergy and Immunology

    Background:

    • Systemic mastocytosis (SM) diagnosis is increasing with advanced histamine assays.
    • Urticaria-angioedema is a common presentation of mast cell activation.

    Observation:

    • Over 12 months, 490 new patients were evaluated.
    • 52 patients had urticaria-angioedema; 10 showed evidence of excess histamine/PGD2 and elevated skin mast cells.

    Findings:

    • The average age of patients with mastocytosis was 35.
    • Mastocytosis symptoms included flushing, GI distress, syncope, urticaria-angioedema, pruritus, and headache.
    • Treatment involved H1/H2 antagonists, cyclo-oxygenase inhibitors for syncope, and epinephrine for hypotension.

    Implications:

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  • Early diagnosis and targeted therapies improve outcomes for systemic mastocytosis.
  • Understanding mast cell mediator effects is crucial for managing related conditions.
  • Further research into mast cell activation syndromes is warranted.