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Ischemic Conditioning Attenuates Platelet-Mediated Thrombosis: A Tale of Reverse Translation

Karin Przyklenk1,2,3, Peter Whittaker1,2

  • 11 Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA.

Journal of Cardiovascular Pharmacology and Therapeutics
|August 11, 2017
PubMed

Insights

Ischemic conditioning benefits the heart beyond direct effects on heart cells. This review explores the links between ischemic conditioning, platelet function, and cardioprotection.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Molecular Medicine

Background:

  • Ischemic conditioning (IC) confers cardiac protection, but its mechanisms are not fully understood.
  • Evidence suggests IC's benefits extend beyond direct cardiomyocyte effects.
  • Platelet activation and aggregation are critical in cardiovascular events and recovery.

Purpose of the Study:

  • To review the current understanding of the relationship between ischemic conditioning, platelet activation-aggregation, and cardioprotection.
  • To highlight the complex interplay between these factors in the context of cardiac health.
  • To identify gaps in knowledge regarding the non-cardiomyocyte-specific effects of IC.

Main Methods:

  • Literature review of preclinical and human studies.
  • Synthesis of data on ischemic conditioning protocols and outcomes.
  • Analysis of studies investigating platelet responses to ischemic conditioning.

Main Results:

  • Favorable cardiac outcomes of IC are observed in both preclinical models and human studies.
  • Platelet activation and aggregation are implicated in the cardioprotective effects of IC.
  • The precise mechanisms linking IC, platelet function, and cardioprotection are still being elucidated.

Conclusions:

  • Ischemic conditioning offers cardioprotection through mechanisms involving platelets, not just cardiomyocytes.
  • Further research is needed to fully elucidate the complex interactions between IC, platelet dynamics, and cardiac protection.
  • Understanding these relationships may lead to novel therapeutic strategies for heart conditions.

Keywords:
P-selectinischemic preconditioningmonocyte–platelet aggregatesneutrophil–platelet aggregatesplateletremote ischemic conditioningthrombosis

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