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Updated: Feb 25, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus
Wai Man Mandy Chan1, Shiu Ming Pang2, See Ket Ng1
1National Skin Centre, Department of Dermatology, Singapore.
Abstract:
Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. We will discuss the clinical and histological features of lupus cheilitis.
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