Related Experiment Video

Updated: Feb 24, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.1K

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi1, Jin Zhang1, Xinbin Chen1

  • 1Comparative Oncology Laboratory, School of Veterinary Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA.

Translational Cancer Research
|August 11, 2017
PubMed

Insights

Tumor suppressor p53, crucial for genomic stability, is regulated by RNA-binding proteins (RBPs). Understanding these RBP interactions offers potential cancer therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • The tumor suppressor p53 is vital for genomic integrity and preventing cancer.
  • p53 acts as a transcription factor, controlling genes for cell cycle arrest, senescence, autophagy, and apoptosis.
  • p53 is frequently mutated in various cancers, and its activity is regulated by transcriptional and posttranslational modifications.

Purpose of the Study:

  • To review the posttranscriptional regulation of p53 and its family members by RNA-binding proteins (RBPs).
  • To explore the reciprocal feedback pathways involving RBPs and p53 family members.
  • To highlight the therapeutic potential of understanding p53 regulation by RBPs in cancer treatment.

Main Methods:

  • Literature review focusing on posttranscriptional regulation of p53.
  • Analysis of studies detailing RNA-binding protein interactions with p53 and its family members.
  • Examination of feedback mechanisms between RBPs and p53 family members.

Main Results:

  • p53 and its family members are subject to posttranscriptional regulation by numerous RBPs.
  • Reciprocal feedback loops exist between specific RBPs and p53 family members, influencing their activity.
  • These regulatory interactions present novel targets for cancer therapy.

Conclusions:

  • RNA-binding proteins play a significant role in the posttranscriptional control of p53 and its family.
  • Targeting RBP-p53 interactions offers a promising avenue for developing new cancer therapeutics.
  • Further research into these complex regulatory networks is warranted for clinical applications.
Keywords:
RNA-binding proteins (RBPs)Rbm38p53post-transcriptional regulation

More Related Videos

Purification of Ubiquitinated p53 Proteins from Mammalian Cells10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

2.8K
Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

262

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.8K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.4K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.2K