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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Advancing the Use of Tissue Chip Technology for Studying Human Tissues
09:10

Author Spotlight: Advancing the Use of Tissue Chip Technology for Studying Human Tissues

Published on: January 12, 2024

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Tissue chips - innovative tools for drug development and disease modeling.

L A Low1, D A Tagle

  • 1National Center for Advancing Translational Sciences, National Institutes of Health, 6701 Democracy Boulevard, Bethesda, MD 20892, USA. danilo.tagle@nih.gov.

Lab on a Chip
|August 11, 2017
PubMed
Summary

Microphysiological systems (MPS), or organs-on-chips, offer a promising solution to improve drug development and disease modeling. These advanced tissue chips can enhance drug screening, disease research, and personalized medicine approaches.

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Drug Development

Background:

  • High failure rates in drug development necessitate innovative approaches.
  • Microphysiological systems (MPS) and organs-on-chips leverage tissue engineering and microfabrication.
  • These systems mimic human organ function for advanced research applications.

Purpose of the Study:

  • To explore the transformative potential of tissue chips in drug development and disease modeling.
  • To discuss the application of MPS in drug screening, safety testing, and understanding disease pathologies.
  • To highlight the future role of tissue chips in precision medicine and clinical trials.

Main Methods:

  • Utilizing tissue engineering and microfabrication techniques to create functional organ models.
  • Employing organs-on-chips for drug screening and safety assessments.
  • Developing disease models on chips to study mechanisms and therapeutic responses.

Main Results:

  • Tissue chips show potential to revolutionize early-stage drug development by improving screening and safety testing.
  • These systems provide novel tools for understanding disease mechanisms and evaluating new therapies.
  • Future applications include clinical trials-on-chips for personalized medicine.

Conclusions:

  • Organs-on-chips represent a significant advancement with broad applications in medicine and pharmacology.
  • Tissue chips offer a path towards more efficient drug development and personalized treatment strategies.
  • Addressing current challenges is key to realizing the full potential of this technology.