Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Muscular Thin Films for Label-Free Mapping of Excitation Propagation in Cardiac Tissue.

Annals of biomedical engineering·2020

Same author

Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells.

PLoS computational biology·2019

Same author

Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation.

PloS one·2019

Same author

Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes.

Bioscience reports·2019

Same author

Photocontrol of Voltage-Gated Ion Channel Activity by Azobenzene Trimethylammonium Bromide in Neonatal Rat Cardiomyocytes.

PloS one·2016

Same author

Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue.

PloS one·2015

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Biocontractile microfluidic channels for peristaltic pumping.

Angelina V Shutko¹, Vasily S Gorbunov¹, Konstantin G Guria²

¹Laboratory of Biophysics of Excitable Systems, Moscow Institute of Physics and Technology, 9 Institutskiy per., Dolgoprudny, Moscow Region, Russian Federation, 141701.

Biomedical Microdevices

|August 11, 2017

Summary

This study introduces a novel bio-actuated micro-pump using a contractile channel wall for fluidic flow. This innovation offers controlled, power-free fluid manipulation for lab-on-chip applications.

Keywords:

Bio-microdevices Cardiomyocytes Micro-pump Microfluidics Tissue engineering

More Related Videos

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Feb 24, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Area of Science:

Biomedical Engineering
Microfluidics
Cellular Engineering

Background:

Existing bio-actuated micro-pumps rely on external forces, posing risks to biological samples.
Previous designs utilized cardiomyocites' contractile force but lacked directional control.
Lab-on-chip systems require efficient, safe, and controllable microfluidic pumping mechanisms.

Purpose of the Study:

To develop a novel bio-actuated micro-pump with a contractile channel wall.
To demonstrate directional fluid flow generation using peristaltic wall motion.
To explore the potential for controlled fluid delivery in microfluidic devices.

Main Methods:

Fabrication of a microfluidic channel with a contractile wall.
Induction of excitation-contraction waves along the channel surface.
Tracking of polystyrene microspheres to visualize and quantify fluid flow.
Analysis of flow directionality and velocity.

Main Results:

Successful generation of directional fluid flow within the microfluidic channel.
Observed average flow velocity of 6-8 μm/min in the direction of wave propagation.
Demonstrated control over the pumping direction.
Polystyrene microspheres confirmed unidirectional movement.

Conclusions:

The novel contractile-walled micro-pump effectively generates directional fluid flow.
This bio-actuated peristaltic pump offers controllable fluid transport for lab-on-chip systems.
The design holds promise for targeted delivery applications and future microfluidic advancements.