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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Feb 24, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations.

C C Villette¹, A T M Phillips²

¹Structural Biomechanics, Department of Civil and Environmental Engineering, Imperial College London, London, UK. claire.villette11@imperial.ac.uk.

Biomechanics and Modeling in Mechanobiology

|August 11, 2017

Summary

This study introduces trabecular reorientation into bone adaptation models, predicting functional tissue adaptation in the femur. The approach accurately models trabecular tracts with minimal computational cost.

Keywords:

Bone remodelling Mesoscale Metamodel Microscale Poroelastic Structural

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Last Updated: Feb 24, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

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Area of Science:

Biomechanics
Computational biology
Bone physiology

Background:

Bone functional tissue adaptation is a complex physiological process.
Previous models predicted internal femur structure based on loading but lacked trabecular reorientation.
Osteoclasts and osteoblasts are key cells in bone adaptation.

Purpose of the Study:

To incorporate trabecular reorientation into a phenomenological bone adaptation model.
To achieve this at a limited computational cost.
To predict functional adaptation in a simplified proximal femur model.

Main Methods:

Developed a metamodel from poroelastic microscale continuum simulations.
Integrated the metamodel into a phenomenological mesoscale structural model.
Applied the model to a simplified proximal femur structure.

Main Results:

Successfully predicted the formation of clear, smooth trabecular tracts.
The predicted tracts corresponded to known major trabecular groups in the femur.
The model achieved functional adaptation prediction with minimal computational expense.

Conclusions:

Trabecular reorientation can be effectively modeled within a phenomenological framework.
This approach offers a computationally efficient method for predicting bone functional adaptation.
The findings enhance our understanding of bone's response to mechanical stimuli.