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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Updated: Feb 24, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Dermatofibrosarcoma Protuberans.

Alvaro E Acosta1, Catalina Santa Vélez2

  • 1Dermatology Department, Instituto Nacional de Cancerología, Universidad Nacional de Colombia, Carrera 19C No. 90-14, Bogotá, Colombia. aeacostam@unal.edu.co.

Current Treatment Options in Oncology
|August 11, 2017
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) is a challenging tumor requiring a multidisciplinary surgical approach. Mohs micrographic surgery (MMS) is preferred, but wide local excision (WLE) with clear margins is an alternative for advanced DFSP cases.

Keywords:
Dermatofibrosarcoma protuberansImatinib mesylateMohs micrographic surgeryPathologyRadiotherapySurgery

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Area of Science:

  • Surgical Oncology
  • Dermatopathology
  • Tumor Biology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a slow-growing skin tumor with low metastatic potential but high local destructive capacity.
  • Effective management of DFSP necessitates a multidisciplinary approach to achieve optimal oncological, functional, and aesthetic outcomes.

Purpose of the Study:

  • To discuss the surgical management of Dermatofibrosarcoma protuberans (DFSP).
  • To highlight the role of Mohs micrographic surgery (MMS) and wide local excision (WLE) in DFSP treatment.
  • To emphasize the importance of a multidisciplinary team in managing advanced DFSP cases.

Main Methods:

  • Review of treatment strategies for DFSP, focusing on surgical techniques.
  • Discussion of Mohs micrographic surgery (MMS) as a preferred method.
  • Consideration of wide local excision (WLE) with clear margins when MMS is unavailable.

Main Results:

  • MMS is the preferred surgical method for DFSP when available.
  • For advanced cases or when MMS is unavailable, WLE with at least 2-3 cm margins and thorough pathological assessment is recommended.
  • Confirmation of tumor extirpation before reconstruction is crucial.

Conclusions:

  • DFSP treatment often requires collaboration among various surgical specialties.
  • Further research is needed to compare MMS and WLE for DFSP.
  • Investigating targeted therapies like imatinib for recurrent or metastatic DFSP is warranted.