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Do ANGPTL-4 and galectin-3 reflect the severity of coronary artery disease?

Luxitaa Goenka1, Melvin George2, Vishakha Singh3

  • 1Department of Clinical Pharmacology, SRM MCH & RC, Kattankulathur, Chennai, Tamil Nadu, India.

Therapeutic Advances in Cardiovascular Disease
|August 11, 2017
PubMed

Insights

Biomarkers angiopoietin-like 4 (ANGPTL-4) and galectin-3 were evaluated for assessing coronary artery disease (CAD) severity. Results indicate these biomarkers do not reliably reflect CAD severity, suggesting further research is needed for their role in CAD management.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Clinical Chemistry

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Investigating novel biomarkers is crucial for understanding and managing CAD.
  • ANGPTL-4 and galectin-3 are potential biomarkers for cardiovascular conditions.

Purpose of the Study:

  • To determine if angiopoietin-like 4 (ANGPTL-4) and galectin-3 levels correlate with the severity of coronary artery disease (CAD).
  • To assess the utility of ANGPTL-4 and galectin-3 as diagnostic or prognostic indicators in patients with varying degrees of CAD.

Main Methods:

  • Serum levels of ANGPTL-4 and galectin-3 were measured in 226 patients with different CAD classifications and normal controls using ELISA.
  • Correlations were analyzed between biomarker levels and established CAD severity scores (GRACE and GENSINI) using Spearman's rank correlation and multivariate analysis.

Main Results:

  • Both ANGPTL-4 and galectin-3 were found to be significantly elevated in CAD patients compared to controls.
  • While some correlations were observed between ANGPTL-4/galectin-3 and CAD severity scores in specific patient subgroups, these relationships were not consistently significant.
  • Multivariate analysis did not sustain a significant correlation between ANGPTL-4 or galectin-3 and overall CAD severity.

Conclusions:

  • ANGPTL-4 and galectin-3 do not appear to be reliable biomarkers for assessing the severity of coronary artery disease.
  • Further research is warranted to explore the potential role of these biomarkers in the broader management strategies for CAD.
  • The findings suggest current evidence does not support routine clinical use of ANGPTL-4 and galectin-3 for CAD severity assessment.
Abstract

Keywords:
CADGRACE scoreangiopoietin-like 4galectin-3

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