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Quantifying Myeloperoxidase-DNA and Neutrophil Elastase-DNA Complexes from Neutrophil Extracellular Traps by Using a Modified Sandwich ELISA
Published on: May 12, 2023
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[Neutrophil extracellular traps and coagulation dysfunction in sepsis]
Fangxiao Zhang1, Zhidan Zhang, Xiaochun Ma
1Department of Critical Care Medicine, the First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China. Corresponding author: Zhang Zhidan,
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|August 11, 2017
Summary
Neutrophil extracellular traps (NETs) restrict pathogens but can cause blood clotting issues in sepsis and venous thrombosis. These structures may serve as biomarkers for coagulation dysfunction and potential therapeutic targets.
Area of Science:
- Immunology
- Hematology
- Pathophysiology
Background:
- Neutrophil extracellular traps (NETs) are DNA and protein structures released by activated neutrophils.
- NETs function as a defense mechanism against pathogens.
- However, NETs are implicated in thrombosis and sepsis-related coagulopathy.
Purpose of the Study:
- To investigate the role of NETs in sepsis and venous thrombosis.
- To explore NETs as potential biomarkers for coagulation dysfunction.
- To evaluate NETs as therapeutic targets in sepsis.
Main Methods:
- Literature review on NETs' role in inflammation and coagulation.
- Analysis of studies linking NETs to sepsis-induced coagulopathy.
- Examination of research on NETs in venous thrombosis pathogenesis.
Main Results:
- NETs contribute to neutrophil-platelet adhesion and procoagulant activity.
- NETs can cause endothelial cell damage, exacerbating coagulopathy in sepsis.
- NETs are significantly involved in the pathophysiology of venous thrombosis.
Conclusions:
- NETs play a dual role in host defense and pathological thrombosis.
- NETs are potential biomarkers for assessing coagulation disorders in sepsis.
- Targeting NETs may offer a novel therapeutic strategy for sepsis and thrombosis.
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