Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.5K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.5K
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

23.2K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
23.2K
Signs of Puberty01:27

Signs of Puberty

1.7K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.7K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

2.2K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
2.2K
Menopause01:28

Menopause

5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of menopausal hormone therapy on cardiovascular disease, cancer, cognition and depression in younger women: A systematic review.

JRSM open·2026
Same author

Redefining Pain and Addiction: How Opioid Manufacturers Changed Medical Language to Foster Opioid Use.

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics·2026
Same author

Response to Mr. DiNardo's "Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products".

Critical reviews in toxicology·2026
Same author

Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products.

Critical reviews in toxicology·2026
Same author

Comprehensive review of ensulizole toxicology data and human exposure assessment for personal care products.

Critical reviews in toxicology·2025
Same author

Comprehensive review of avobenzone (butyl methoxydibenzoylmethane) toxicology data and human exposure assessment for personal care products.

Critical reviews in toxicology·2025

Related Experiment Video

Updated: Feb 24, 2026

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.7K

Testosterone and sexual function.

Adriane Fugh-Berman1, Anthony R Scialli

  • 1aDepartment of Pharmacology and Physiology, Georgetown University Medical Center bDepartment of Obstetrics and Gynecology, George Washington University School of Medicine, and Scialli Consulting LLC, Washington, District of Columbia, USA.

Current Opinion in Urology
|August 11, 2017
PubMed
Summary
This summary is machine-generated.

Testosterone therapy offers limited benefits for sexual function in aging men. Potential cardiovascular risks outweigh the inconsistent improvements, arguing against its widespread use.

More Related Videos

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.1K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.8K

Related Experiment Videos

Last Updated: Feb 24, 2026

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

15.7K
Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.1K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.8K

Area of Science:

  • Endocrinology
  • Gerontology
  • Sexual Medicine

Background:

  • Testosterone therapy is sometimes recommended for age-related symptoms.
  • Its efficacy for improving sexual function in aging men is debated.
  • Randomized clinical trials (RCTs) provide key evidence.

Purpose of the Study:

  • To review RCTs on testosterone therapy's effects on sexual function.
  • To evaluate the overall benefit-risk profile for aging men.

Main Methods:

  • Systematic review of randomized clinical trials.
  • Analysis of effects on various domains of sexual function.
  • Assessment of reported adverse events, including cardiovascular risks.

Main Results:

  • Approximately 50% of RCTs showed no improvement in sexual function.
  • When benefits were observed, they were often limited to specific domains.
  • Erectile dysfunction treatment with testosterone therapy yielded disappointing results.
  • Increased risk of thromboembolic and cardiovascular events was noted.

Conclusions:

  • Limited and inconsistent benefits for sexual function.
  • Significant potential risks, including cardiovascular issues.
  • Recommends against testosterone therapy for aging men, even with low testosterone levels.