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Update on bicuspid aortic valve aortopathy

Evaldas Girdauskas1, Johannes Petersen

  • 1Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany.

Current Opinion in Cardiology
|August 11, 2017
PubMed

Insights

New biomarkers show promise for predicting thoracic aortic aneurysm progression in patients with bicuspid aortic valve (BAV) disease. Combining these with imaging and risk factors can improve diagnosis and care.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Biomarker Discovery

Background:

  • Bicuspid aortic valve (BAV) associated aortopathy treatment remains controversial.
  • Current research focuses on predicting disease progression and adverse aortic events.

Purpose of the Study:

  • To summarize recent evidence on predicting aortopathy progression in BAV disease.
  • To identify novel markers for adverse aortic events.

Main Methods:

  • Literature review of recent studies.
  • Analysis of hemodynamic and blood-born biomarkers.
  • Exploration of genetic analyses.

Main Results:

  • Hemodynamic markers are key to understanding BAV-associated aortopathy progression.
  • Blood-born biomarkers offer a promising approach for predicting adverse aortic events.
  • Genetic factors are under investigation.

Conclusions:

  • Serological biomarkers are valuable for screening and predicting thoracic aortic aneurysmal disease.
  • Integrating biomarkers with rheological imaging and risk factors enhances diagnostic accuracy and cost-effectiveness for BAV-associated aortopathy.
Abstract

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