Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fundamental limits of non-Hermitian sensing from quantum Fisher information.

Reports on progress in physics. Physical Society (Great Britain)·2026

Same author

Prevalence and antimicrobial susceptibility of <i>Staphylococcus aureus</i> isolated from dairy goats in Shaanxi, China, with genomic characterization of a multidrug-resistant subset.

One health (Amsterdam, Netherlands)·2026

Same author

Genetic background and plasmid-associated contig profiles of the beta-2 toxin coding genes cpb2 and atypical cpb2 in Clostridium perfringens.

BMC genomics·2026

Same author

Deformation engineering enables precise dispersion control in an optical microcavity.

Light, science & applications·2026

Same author

Covalent Organic Framework with Tailored Angstrom-Scale Motifs for Efficient Water Activation and Desalination.

ACS applied materials & interfaces·2026

Same author

Research and Application of Mining-Induced Fracture Evolution and the Mechanism of Pressure Relief Gas Migration and Storage in Overlying Strata during Soft Rock Protective Layer Mining.

ACS omega·2026

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

$Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing$

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

Exceptional points enhance sensing in an optical microcavity.

Weijian Chen¹, Şahin Kaya Özdemir¹, Guangming Zhao¹

¹Department of Electrical and Systems Engineering, Washington University, St Louis, Missouri 63130, USA.

|August 11, 2017

Summary

This summary is machine-generated.

Researchers enhanced microcavity sensor sensitivity using exceptional points. This method amplifies the signal from nanoscale objects, enabling unprecedented detection capabilities for advanced sensing applications.

More Related Videos

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Published on: November 30, 2012

Related Experiment Videos

Last Updated: Feb 24, 2026

$Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing$

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Fabrication And Characterization Of Photonic Crystal Slow Light Waveguides And Cavities

Published on: November 30, 2012

Area of Science:

Photonics and optical sensing
Quantum mechanics and non-Hermitian physics

Background:

Optical microcavities enhance light-matter interactions for sensing applications.
Traditional microcavity sensors detect perturbations via resonance shifts or linewidth changes.
Existing methods have limitations in sensitivity for detecting nanoscale objects.

Purpose of the Study:

To demonstrate a novel sensing scheme using exceptional points (EPs) to enhance microcavity sensitivity.
To explore the potential of non-Hermitian degeneracies for improved nanoscale sensing.
To achieve higher sensitivity than traditional sensing schemes.

Main Methods:

Utilized whispering-gallery-mode micro-toroid cavities.
Employed two nanoscale scatterers to precisely tune the microcavity to an exceptional point.
Introduced a target nanoscale object into the evanescent field to perturb the system.
Measured the resulting frequency splitting.

Main Results:

Demonstrated frequency splitting that scales as the square root of the perturbation strength near EPs.
Observed significantly larger frequency splitting for small perturbations compared to traditional methods.
Successfully perturbed the system from its exceptional point with nanoscale objects.

Conclusions:

Exceptional point-enhanced sensitivity offers a new paradigm for microcavity-based sensors.
This approach enables unprecedented sensitivity for detecting nanoscale objects.
Paves the way for next-generation sensors with significantly improved performance.