Related Experiment Video
Updated: Feb 24, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
10.3K
Systemic virotherapy for multiple myeloma
Stefania Oliva1, Manuela Gambella1, Mario Boccadoro1
1a Myeloma Unit, Division of Hematology , University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino , Torino , Italy.
Expert Opinion on Biological Therapy
|August 11, 2017
Summary
Oncolytic virotherapy offers a novel approach to treating multiple myeloma (MM) by targeting cancer cells. This review explores various viruses and their potential in MM treatment and autologous bone marrow transplants.
Area of Science:
- Oncology
- Virology
- Immunotherapy
Background:
- Multiple myeloma (MM) treatment landscape is evolving with novel targeted therapies.
- Oncolytic virotherapy is emerging as a promising strategy for MM treatment.
Purpose of the Study:
- To analyze the mechanisms of action of virotherapy in MM.
- To summarize preclinical and clinical studies of systemic virotherapy for MM.
- To discuss the potential of virotherapy in autologous bone marrow transplantation for MM.
Main Methods:
- Review of preclinical and clinical studies on systemic virotherapy for MM.
- Analysis of mechanisms of action of various oncolytic viruses.
- Identification of viruses studied for MM treatment.
Main Results:
- Several viruses, including adenovirus, vaccinia virus, and reovirus, show potential for MM treatment.
- Virotherapy can be used alone, with chemotherapy/radiotherapy, or for purging myeloma cells from bone marrow transplants.
- Antiviral immune responses can limit the efficacy of virotherapy.
Conclusions:
- Oncolytic viruses offer multifaceted therapeutic potential in multiple myeloma.
- Further research is needed to optimize therapeutic combinations and overcome immune-related limitations.
- Virotherapy represents a significant advancement in the evolving MM treatment paradigm.
More Related Videos
08:52Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
17.8K
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.9K
Related Concept Videos
02:49Cancer Therapies
10.3K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.3K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
01:29Subviral Agents
653
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
653
01:03Rous Sarcoma Virus (RSV) and Cancer
6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.5K
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K